Cancer-fighting properties of papaya

(AFP) – Researchers said Tuesday that papaya leaf extract and its tea have dramatic cancer-fighting properties against a broad range of tumors, backing a belief held in a number of folk traditions.

University of Florida researcher Nam Dang and colleagues in Japan, in a report published in the Journal of Ethnopharmacology, documented papaya’s anticancer effect against tumors of the cervix, breast, liver, lung and pancreas.

The researchers used an extract made from dried papaya leaves, and the effects were stronger when cells received larger doses of papaya leaf tea.

Dang and the other scientists showed that papaya leaf extract boosts the production of key signaling molecules called Th1-type cytokines, which help regulate the immune system.

This could lead to therapeutic treatments that use the immune system to fight cancers, they said in the February issue of the journal and released Tuesday by the university.

Papaya has been used as a folk remedy for a variety of ailments in many parts of the world, especially Asia.

Deng said the results are consistent with reports from indigenous populations in Australia and his native Vietnam.

The researchers said papaya extract did not have any toxic effects on normal cells, avoiding a common side effect of many cancer treatments.

Researchers exposed 10 different types of cancer cell cultures to four strengths of papaya leaf extract and measured the effect after 24 hours. Papaya slowed the growth of tumors in all the cultures.

Dang and a colleague have applied to patent the process to distill the papaya extract through the University of Tokyo.

What’s new in bypass vs. stent

By Tyrone M. Reyes, M.D.

When cholesterol-filled plaque severely narrows a coronary artery and causes chest pain or other symptoms, there are two ways to immediately improve blood flow — angioplasty, usually with the placement of a wire-mesh stent, or bypass artery surgery (see illustration). If the blockage is simple and confined to a single artery, angioplasty is often a good choice. It is quick and effective, and since it doesn’t require opening the chest, the recovery time is short. For more severe or complicated problems, doctors have traditionally relied on bypass surgery. This has long been the approach taken for the left main coronary artery before it divides into two branches (see illustration). This is a serious problem because the left main coronary artery nourishes such a wide expanse of heart muscle. Bypass surgery has also traditionally been performed for three-vessel disease, which covers simultaneous blockages in the left anterior descending artery, the circumflex artery, and the right coronary artery.

Advances in angioplasty, especially in stent design, have prompted interventional cardiologists (the doctors who do angioplasty) to push the envelope in the types of coronary disease (CAD) they tackle. Some have been using angioplasty and stents for left main coronary artery disease and three-vessel disease. How well angioplasty works in these situations is controversial. Earlier trials suggested that bypass surgery was superior for these complex cases, but most of the trials were done before the advent of the latest generation of artery-opening stents. That gap has been temporarily plugged by the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) trial. (Percutaneous coronary intervention or PCI is medicalese for angioplasty, with percutaneous meaning through the skin.) Results of the SYNTAX trial were published in the March 5, 2009 issue of the New England Journal of Medicine (NEJM).

You Have A Choice

The study concluded that surgery was still the standard of care for patients with three blocked coronary arteries or left main coronary artery disease. The main lesson from SYNTAX, however, is not that surgery or stenting is better for left main or three-vessel coronary artery disease. Instead, it is that you have a choice, depending on the anatomy of your heart, the number and location of your blockages, and your other health issues.

“There are certain patients who would be better served by stents and others who do better with surgery,” says Joseph Sabik, MD, chairman of thoracic and cardiovascular surgery at the Cleveland Clinic. “What has to happen is patients have to be informed of the risks and benefits of each procedure so they can make an informed decision.”

Do You Need Revascularization?

In January 2009, a panel of experts unveiled the criteria for using revascularization (angioplasty or bypass). Among these are:

• Revascularization is appropriate if the expected improvement in survival, symptoms, function, and/or quality of life outweigh the potential risks.

• Revascularization would be inappropriate in a patient with plaque accumulation in one or two arteries and little muscle at risk, who experienced symptoms only during strenuous exercise, and was not taking medications.

• Conversely, revascularization would be appropriate if a similar patient had severe symptoms despite taking the best available heart medication.

If you’re considering revascularization, here are some questions to ask your cardiologist or surgeon:

• Which coronary artery is blocked, and is the location of the blockage more suitable for stenting or surgery?

• Will this procedure help me feel better? Live longer?

• Is medical therapy as effective in terms of helping me feel better and live longer?

• If I have a stent implanted, will I need bypass surgery three to five years from now?

• If I choose surgery, which bypass grafts are you going to use? (Arteries from the chest and the radial artery in the arm may last longer than the saphenous veins from the legs.)

• How much experience do you have in my procedure of choice?

Making The Right Choice

Angioplasty is less expensive and allows for a faster recovery, and advances in stent technology have reduced the rate of renarrowing (restenosis) of the blocked arteries. On the downside, angioplasty patients must take medications such as clopidogrel (Plavix), which prevents clots from forming in the stent but also increases the risk of bleeding.

Bypass surgery is painful and requires longer hospital stay and several months of recovery. “The benefit, though, is that it’s our best long-term solution to these problems,” Dr. Sabik says. Bypass surgery is becoming less invasive, he adds, and for many patients, the operation can now be performed through small incisions in the side of the chest rather than requiring the sternum (breastbone) to be split.

Although SYNTAX and other studies suggest that surgery may be best for patients with severe CAD, Dr. Sabik says that may not be the case for every patient, especially those with co-morbid conditions who aren’t healthy enough for surgery. Angioplasty also may be more appropriate for patients with single-vessel CAD, particularly involving the right coronary or circumflex arteries, he adds.

He recommends that patients meet with cardiologists and surgeons to weigh their options and decide on the best course of action. “You have to take each patient and look at them as an individual, look at what you’re trying to accomplish, and make sure the treatment is right for them, considering who they are and what problems they have,” Dr. Sabik elaborates.

Complementary, Not Competitve

The future of revascularization may lie in a combination approach. For instance, surgery might be done to bypass blocked left main coronary artery, while a stent might be used to open a blocked right coronary artery. These hybrid procedures allow people to reap the benefits of both approaches.

“We have to think about these two procedures not so much as competitive anymore but as complementary,” he says. “The best approach might be a combination of what the cardiologists do and what the surgeons do, taking the best of both and treating the patient as an individual.”

• Reference: The Syntax Trial, New England Journal of Medicine, March 5, 2009

• Sources: “Trial renews surgery vs. stent debate,” May 2009

Harvard Health Publications

heart_letter@hms.harvard.edu.

“Which option is best to reopen blocked coronary arteries?”

Cleveland Clinic Health Advisor, July 2009

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Love, sex, and health

Tyrone M. Reyes, M.D.

We pay tribute to love on St. Valen-tine’s Day, but is the hoopla really warranted from a health standpoint? After all, love and its libidinous soul mate, passion, have led to countless calamities — some of them spectacularly tragic but most anonymously sad: the unrequited romance, the bad marriage, the ill-fated affair. As a mental state, love really can’t be considered healthy: no one in his or her right — which is to say normal, rational — mind, is ever in love. To be in love is to be madly so. In Civilization and its Discontents, Freud goes out of his way not to stigmatize love as a pathology. Yet, he also describes it as having the pathological quality of blurring the boundary between the ego, the sense of self, and the external world. “Against all the evidence of his senses,” wrote Freud, “a man who is in love declares that ‘I’ and ‘you’ are one, and is prepared to behave as if it were fact.” Harvard psychiatrist Lester Grinspoon quips that “romantic love and adolescence are the only two socially acceptable forms of psychosis.”

“People compose poetry, novels, sitcoms for love,” says Helen Fisher, an anthropologist at Rutgers University in New Jersey, and something of the Queen Mom of romance research. “Some people live for love, die for love, kill for love. It can be stronger than “the drive to stay alive.”

Sexual Healing

The fact is, love and sex leave their mark, not just on the mind but on the body as well. Researchers have begun to explore their effects on almost every part of the body, from the brain to the heart to the immune system. Studies show that arousal and an active sex life may lead to a longer life, better heart health, an improved ability to ward off pain, a more robust immune system, and even protection against certain cancers, not to mention lower rates of depression.

Here is what doctors and scientists have learned so far about the positive effects of sexual activity on health:

• Heart disease. Lovemaking is good aerobic exercise that improves the circulation and works the heart. Sexually active people tend to suffer from fewer heart attacks, possibly owing to their better fitness.

The act of intercourse burns about 200 calories. During orgasm, both heart rate and blood pressure typically double. It would be logical to conclude that sex, like other aerobic workouts, can protect against heart disease, but studies to support this link have yet to be done.

• Pain control. Endorphins released during orgasm can dull the chronic pain of backaches and arthritis, as well as migraines.

In the 1970s, Dr. Beverly Whipple of Rutgers University, identified the female G spot, the vaginal on-switch for female arousal. Whipple showed that gentle pressure on the G spot raised pain thresholds by 40 percent and that during orgasm, women could tolerate up to 110 percent more pain. But she could not explain the link until the advent of functional magnetic resonance imaging (fMRI). Using fMRI to view the brains of orgasmic women as they climaxed, Whipple found that the midbrain is activated during peak arousal. Signals from this part of the brain instruct the body to release endorphins and corticosteroids, which can temporarily numb the raw nerve endings responsible for everything, from menstrual cramps to arthritis and migraine for several minutes. Activating the region also reduces anxiety and has a calming effect.

• Immunity. Frequent intercourse may boost levels of key immune cells that help fight off colds and other infections.

A trial involving more than 100 college students in 1999 found that the levels of immunoglobulin, a microbe-fighting antibody, in students who engaged in intercourse once or twice a week were 30 percent higher than in those who were abstinent.

• Cancer. Early studies hint that oxytocin, and the hormone DHEA, both released during orgasm, may prevent breast cancer cells from developing into tumors.

In addition, frequent sexual activity has been tied to lower risk of breast cancer in women and prostate cancer in men, a relationship that is still not fully understood but may involve some interaction between oxytocin and the sex hormones estrogen and progesterone, and their roles in cell signaling and cell division.

• Longevity. It’s well known that married folk tend to live longer and suffer less depression than singles do. But is this because of more frequent sex, simple companionship or some benign aspect of personality that lends itself to marriage? Teasing apart such matters is difficult, but sex itself appears to be a factor. A study of 3,500 Scottish men, for example, found a link between frequent intercourse and greater longevity.

Romantic Love

The giddy state of sexual activity is one thing, long-term romantic love is another; surely, the steadier state must be good for us, too. Indeed, married people do enjoy better physical and mental health than unmarried people, according to a wide range of health studies.

But not all married couples live in conjugal bliss, and marital conflict can be a source of tremendous stress, which has a variety of well-documented negative effects filtered by the body’s nervous and hormonal systems. Several years ago, Ohio State University researchers set out to measure the consequences of marital squabbling. They organized a study of 31 older couples whose average age was 67 and who had been married for an average of 42 years. An interviewer led them to and through a discussion of acrimonious issues like in-laws and finances, and then their blood was tested for hormonal and immunological responses. Among the women, these lab-orchestrated spats led to several stress-related hormonal changes and a marked dampening of the immune system. Among the men, only the immune system was affected. The researchers concluded in their 1997 article in Psychosomatic Medicine that abrasive marriages may make some older people more vulnerable to infections and slower to heal.

Social And Emotional Support

In recent years, health researchers have assembled a large body of evidence that argues that older people embedded in social networks of friends, relatives, children, and confidants tend to be healthier and recover faster from many illnesses.

A recent social network study hints that, at least among the elderly, being liked may be more important to health than being loved, which can lead to an intense, but often problematic, relationship. A study of disability among 2,812 elderly residents of New Haven, Connecticut, found that lower risks for disability were not associated with emotional support from children or confidants, the very relationships that seem most likely imbued with love. Instead, emotional support from friends and relatives was the key. The researchers speculated that relationships with friends and relatives promote motivational and coping strategies, such as a sense of control and self-efficacy which help fend off depression, anxiety, and other psychological states that feed into disability. Relationships with children are less discretionary, they noted, and may therefore be associated with both benefits and strains.

Love Medicine

But don’t give up on the health benefits of love as yet. It is possible, and maybe even probable, that it is really love, and not just congeniality, that is circulating through those health-conferring networks of friends and relatives.

Parental love seems to be a very potent preventive medicine. Results of the Harvard Mastery of Stress Study published in 1997 showed that 87 percent of male participants who rated their parents as uncaring had had a major medical illness by the time they reached their mid-50s. Only 25 percent of the men who rated their parents as loving and caring had had a major illness.

And finally, of course, there is sex. We already know that you could fill a truck with studies that have shown that sex is good for your health. Of course, some people have sex without love all the time, but no one has yet invented a better aphrodisiac than falling in love!

Source:philstar.com

Porcelain Veneers or Composite Veneers?

What is a veneer? Veneer is a thin layer of restorative material placed over a tooth surface, either to improve the aesthetics of a tooth, or to protect a damaged tooth surface. There are two main types of material used to fabricate a veneer, composite and dental porcelain. A composite veneer may be directly placed (built-up in the mouth), or indirectly fabricated by a dental technician in a dental laboratory, and later bonded to the tooth, typically using a resin cement such as Panavia. In contrast, a porcelain veneer may only be indirectly fabricated.

The first video below is the hard and torturous one, while the next video is the easy one. Watch both videos before getting a veneer, lolz.

Here is the easy one:

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