Posts Tagged ‘Dementia’

Elderly depression: The age factor in depression 2/2

Depression does not become more common as you get older, but it may become more complex.  Recent findings on age and depression confirm the so-called ‘U-curve’ of well being and happiness over the human life cycle.  Put simply, we’re at our most dissatisfied in our mid-forties – a finding that’s so in 47 of 55 countries surveyed. Depression seems to have much less of an impact in terms of daily disability in the older age groups.

But depression in the elderly is complicated by other diseases and it’s often hard to sort out cause and effect. Do you get depressed because you’ve had a heart attack? Does depression make it more likely that you’ll get diabetes? We really don’t know! Elderly depression is not so much about the numbers of people who are depressed, but more a matter of knowing how best to treat it.  Higher costs in terms of time, money and health care resources are involved in treating elderly depression and, too often, such resources simply aren’t adequate.  Moreover, the growing number of people over 60 (and, proportionately, even more so those over 80), means that elderly depression is set to rise dramatically. As yet, society seems unprepared for this.   Recent findings from the Zürich Study of younger persons (stretching over 20 years and with an age range of 20-41) have pointed to high levels of chronic depression existing alongside heart and lung problems, insomnia, pain (other than backache and headache) and sexual problems. Interestingly, the authors ascribe the heart and lung problems   in this age group as probably ‘associated with increased anxiety’.

In the elderly, by contrast, depression tends to exist alongside age-related conditions like stroke, high blood pressure, atrial fibrillation, diabetes, cancer and dementia.

The Zürich Study also found that other mental health problems co-exist with depression in the   20-41 age group. The six leading risk factors were found to be tobacco dependence, substance abuse, generalized anxiety disorder, obsessive-compulsive syndrome, panic attacks and alcohol use disorder. Again, with the exception of anxiety, these are probably more prominent risk factors for depression in younger persons than for the elderly. The psychosocial impact of bereavement, loneliness and growing physical and cognitive problems in coping with the normal activities of daily life are more characteristic associations with depression in old age.

The next article in this series looks at current   practice in the diagnosis and treatment of elderly depression.

 

Sources:

J. Angst, A. Gamma et al, “Long-term depression versus episodic major depression: results from the prospective Zürich study of a community sample”, J. Affective Disorders 115, 112-121, 2009
N. G. Choi & J. S. Kim, “Age group differences in depressive symptoms among older adults with functional impairments”, Health & Social Work 32[3], 177-188, August 2007

 

Related article:
Elderly and depression: How to understand Depression in the elderly 1/2

Created on: 11/04/2009
Reviewed on: 11/04/2009

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Mediterranean Diet and Physical Activity Reduce Alzheimer’s Risk

 Previous studies have shown that a Mediterranean diet and higher physical activity are each associated with a lower risk of Alzheimer’s disease.

However, the combined association of Mediterranean diet and more physical activity on Alzheimer’s risk is not well-studied. In the August 12, 2009 issue of Journal of the American Medical Association, researchers report that both eating well and participating in physical activity may independently confer Alzheimer’s disease-related health benefits.

 

Researchers from Columbia University studied 1880 community-dwelling elderly individuals living in New York City who did not have Alzheimer’s dementia. Both diet and physical activity information were available for each of these individuals. The researchers administered neurological and neuropsychological testing approximately every 1.5 years from 1992 through 2006. During this time, a total of 282 cases of Alzheimer’s disease were diagnosed. Both Mediterranean diet and higher levels of physical activity were associated with a lower risk of Alzheimer’s disease.

 

While some may argue that the association between physical activity and Alzheimer’s disease simply reflect that more physically active people are also more likely to eat healthier, this study demonstrates that the associations of diet and physical activity with lower rates of Alzheimer’s disease were independent of each other. Based on this study, even a relatively small amount of physical activity (1.3 hours of vigorous physical activity or 2.4 hours of moderate physical activity or 4 hours of light physical activity per week) was associated with a reduction in Alzheimer’s risk.

 

Source:

JAMA. 2009;302(6):627-637.

Created on: 08/20/2009
Reviewed on: 08/20/2009

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Does Mediterranean Diet Slow Cognitive Decline?

Following a Mediterranean diet has been linked to a lower risk of death and chronic diseases, but the association between Mediterranean diet and dementia risk is more controversial.

In the August 12, 2009 issue of Journal of the American Medical Association, researchers report on a study in which higher adherence to a Mediterranean diet was associated with slower cognitive decline, but only on one neuropsychological test on a consistent basis.

 

Columbia University Medical Researchers and their French colleagues studied 1410 French adults who were at least 65 years of age in order to investigate the association between a Mediterranean diet and changes in cognitive performance and the risk for dementia. Each of the study participants underwent 4 neuropsychological tests to evaluate cognitive performance. After adjusting for age, gender, level of education, marital status, and other dementia risk factors, the researchers found that adherence to a Mediterranean diet was associated with fewer errors on the Mini-Mental State Examination (MMSE). However, performance on three other neuropsychological tests was not consistently associated with Mediterranean diet.

 

The researchers also reported that adherence to a Mediterranean diet was not associated with the risk for incident dementia, however the statistical power of this finding was limited. So, it seems that the association among Mediterranean diet, cognitive decline, and dementia risk still requires further study.

 

Source:

JAMA. 2009;302(6):638-648.

Created on: 08/19/2009
Reviewed on: 08/19/2009

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Alzheimer's disease linked to mid-life cholesterol

Alzheimer’s disease takes many years to develop and, with an aging population, it has become increasingly urgent to discover ways of preventing this, the most common form of dementia, from taking hold. 

Previously,  high cholesterol in mid-life has been linked to an increased risk of Alzheimer’s disease.  Now researchers at Kaiser Permanente’s Research Division and at the University of Kuopio, Finland, unveil the longest, and largest, study to link high cholesterol with Alzheimer’s disease.  They also find a link with vascular dementia,  which suggests some overlap in the two forms of dementia.

A group of nearly 10,000 men and women had their cholesterol levels measured between 1964 and 1973 and were then followed up for around 40 years. During this time, there were 469 patients diagnosed with Alzheimer’s disease and 127 with vascular dementia.  Taking a baseline of less than 220 mg/dL cholesterol, the researchers say that raised levels increase the risk of both Alzheimer’s disease and vascular dementia in later years.  That is, having cholesterol levels higher than 240 mg/dL increases Alzheimer’s disease risk by 66% and even borderline levels, between 220 and 240 mg/dL, increase the risk of both forms of dementia.  This study is notable because it includes a large and diverse group of people – previous studies on Alzheimer’s disease and high cholesterol have been more limited.

Around 100 million Americans are estimated to have cholesterol levels that are higher than desirable. Worse, many do not even know it! The take home message is to be aware of your cholesterol figures (this means total cholesterol but also the high and low density lipoprotein cholesterol figures).  And if they stray beyond desirable levels, there are both lifestyle modifications that can be made and medications, like statins, which are proven effective in cholesterol lowering.  It is surely worthwhile aiming for a healthy cholesterol figure if the payoff is a reduced risk of Alzheimer’s disease and vascular dementia.

Source: 

Solomon A, Kivipelto M et al Midlife serum cholesterol and increased risk of Alzheimer and vascular dementia three decades later Dementia and Geriatric Cognitive Disorders 2009;75-80 (doi: 10.1159/000231980)

Created on: 08/10/2009
Reviewed on: 08/10/2009

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Spinal Tap May Be Able to Predict Alzheimer’s Disease

 Small studies have previously shown that biomarkers in the cerebrospinal fluid, the fluid surrounding the brain and spinal cord, may be useful in identifying which patients with mild cognitive impairment will go on to develop Alzheimer’s disease.

Now, as reported in the July 22/29, 2009 issue of the Journal of American Medical Association, three cerebrospinal fluid (CSF) biomarkers identify incipient Alzheimer’s disease with good accuracy.

 
This study involved a total of 750 individuals with mild cognitive impairment, 529 individuals with Alzheimer’s disease, and 304 controls, all recruited from 12 centers in Europe and the United States. Individuals with mild cognitive impairment were followed for a period of at least 2 years or until they had progressed to dementia. During follow-up, 271 study participants with mild cognitive impairment progressed to Alzheimer’s disease and 59 others were diagnosed with other types of dementia. Three CSF biomarkers, Aβ42,T-tau, and P-tau, were found to be accurate in identifying early-stage Alzheimer’s disease. However, the accuracy reported in this multi-center study was less than that reported in prior single center studies, perhaps due to variability in the assays used to analyze the CSF biomarkers.
 
The ability of CSF biomarkers to accurately identify incipient Alzheimer’s disease has significant clinical implications, since the underlying disease process of Alzheimer’s disease begins long before symptoms progress to dementia. Early identification of Alzheimer’s disease would allow for even earlier initiation of medical interventions that could slow the progression of this debilitating condition.
 
 

Source:

JAMA. 2009;302:385-393.

Created on: 08/04/2009
Reviewed on: 08/04/2009

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