Posts Tagged ‘Diabetes Mellitus’

Diabetes among childhood cancer survivors

Children who survive cancer may be at risk of other diseases in later life, including diabetes.  Researchers at Emory University have carried out a survey of diabetes in 8,599 childhood survivors of cancer and compared them to randomly selected siblings.

The cancer survivors had been diagnosed before the age of 21 and many had been treated with either whole body or abdominal radiation.  The researchers found that 218 (2.5%) of the survivors had diabetes, compared to 49 (1.7%) of their siblings.

 

After taking other factors, like body mass index, age and sex, into account, cancer survivors had a 1.8 times greater diabetes risk.  Thos who had had whole body irradiation, abdominal irradiation and cranial irradiation were at increased risk of diabetes.  With abdominal irradiation, the increased risk of diabetes was 2.7 times and with total body irradiation it was 7.2 times. And those diagnosed with cancer before age 5 were 2.4 times more likely to report diabetes compared to those diagnosed with cancer in late adolescence.  Older age, black or Hispanic/Latino background, lower household income, physical inactivity and increased body mass index were extra risk factors for diabetes in childhood cancer survivors.

 

The findings have two messages. First, childhood cancer survivors should be screened regularly for both pre-diabetes and diabetes so early intervention can be offered.  Second, there is need for further research to find out just why whole body irradiation and abdominal irradiation should set the scene for diabetes in later life. 

Source

Meacham L, Sklar C et al Diabetes mellitus in long-term survivors of childhood cancer: Increased risk associated with radiation therapy: a report for the Childhood Cancer Survival Study Archives of Internal Medicine August 10/24 2009;169:1381-1388

Created on: 09/04/2009
Reviewed on: 09/04/2009

Your rating: None

Diabetes mellitus

by Dr. Gary S. Sy

A LACK as well as an excess of blood sugar (glucose) can be devastating. For this reason, the body strives to maintain blood sugar levels within a narrow range through the coordinated effort of several glands and their hormones. If these control mechanisms are disrupted, diabetes (high blood sugar) or hypoglycemia (low blood sugar) may result.

Normally, the body responds to the rise in blood glucose after meals by secreting insulin, a hormone produced by the beta cells of the pancreas.

Diabetes mellitus is a common disorder that occurs when your pancreas either totally stops producing insulin or does not produce enough of the hormone for your body’s need. This lack of insulin results in a low absorption of glucose, both by the body’s cells, which need it for energy, and by the liver, which stores it and this result in an abnormally high level of glucose in your blood, along with a spillover of some of the excess glucose into the urine.

There are two main forms of Diabetes Mellitus:

1.) Type I (also called juvenile onset or insulin dependent) diabetes – associated with destruction of the beta cells of the pancreas, which manufacture insulin. This type of diabetes occurs mostly in children and young adults. Recent evidence implicates a viral cause in some cases. Symptoms of type I diabetes include irritability, frequent urination, abnormal thirst, nausea or vomiting, weakness, fatigue, weight loss despite a normal (or even increased) intake of food, and unusual hunger. In children, frequent bedwetting – especially by a child who did not previously wet the bed – is another common sign.

2) Type II (non-insulin dependent or maturity onset) diabetes – In this form of diabetes mellitus, which usually affects people over 40, the insulin-producing cells in your pancreas function, but the output of insulin is not adequate for your body’s needs. People who have this form of disorder usually over-eat and are overweight. Heredity is also a factor. In most cases, there is a family history of the disorder. Age is also a factor, because the efficiency of your pancreas decreases as you become older. Symptoms include blurred vision, itching, unusual thirst, drowsiness, fatigue, skin infections, slow wound healing, tingling or numbness in the hands and feet, and loss of weight since the fat and muscle are burned up to provide energy. Other symptoms are reduced resistance to infections (boils, urinary tract infections and fungus vaginal infections are sometimes the first signs of diabetes mellitus), impotence in men, and the absence of menstrual period in women. Certain microorganisms (bacteria) are attracted to sugary urine, and these can cause complications, such as bladder infections and other urinary tract problems.

What are the risks?

Diabetes mellitus becomes increasingly common with age. The type II form occurs most often among those who are overweight, especially middle-aged and older women.

Most people with type II diabetes have a relative with the disease. However, even if both your parents have diabetes there is only a 1:20 risk that you will have it.

The effectiveness of today’s treatment has changed this disease that once was often fatal into one from which deaths are extremely rare. However, there are still risks. People with type I diabetes mellitus may lead to a life-threatening condition called “ketoacidosis” – when the body is unable to use glucose because of lack of insulin, it is forced to obtain energy from fat. As the fat is burned, ketones (a dangerous chemical substance) are produced.

Other conditions that may affect both types of diabetes usually occur 15 to 20 years after the onset of the disease. Such risks include: “diabetic retinopathy” – an eye disorder that causes blindness; “peripheral neuropathy” – a nerve disease and “chronic kidney failure.”

(Dr. Gary S. Sy, MD is the medical director of Life Extension Medical Center located at The Garden Plaza Hotel, (formerly Swiss Inn Hotel), 1370 General Luna St., Paco, Manila. He is a Diplomate in Gerontology and Geriatrics, advocates diet-nutritional therapy, and conducts free seminar every Friday about agerelated health problems. For more details, visit E-mail address: lifeextension_drgarysy@yahoo.comThis e-mail address is being protected from spam bots, you need JavaScript enabled to view it Please tune in at DZRH 666 kHz “Operation Tulong” every Friday at 10 p.m. and DZMM 630 kHz “Gabay sa Kalusugan on Radio” every Sunday at 11 a.m. 12 noon.)

Source: Manila Bulletin

}