Posts Tagged ‘Further Study’

Does Mediterranean Diet Slow Cognitive Decline?

Following a Mediterranean diet has been linked to a lower risk of death and chronic diseases, but the association between Mediterranean diet and dementia risk is more controversial.

In the August 12, 2009 issue of Journal of the American Medical Association, researchers report on a study in which higher adherence to a Mediterranean diet was associated with slower cognitive decline, but only on one neuropsychological test on a consistent basis.

 

Columbia University Medical Researchers and their French colleagues studied 1410 French adults who were at least 65 years of age in order to investigate the association between a Mediterranean diet and changes in cognitive performance and the risk for dementia. Each of the study participants underwent 4 neuropsychological tests to evaluate cognitive performance. After adjusting for age, gender, level of education, marital status, and other dementia risk factors, the researchers found that adherence to a Mediterranean diet was associated with fewer errors on the Mini-Mental State Examination (MMSE). However, performance on three other neuropsychological tests was not consistently associated with Mediterranean diet.

 

The researchers also reported that adherence to a Mediterranean diet was not associated with the risk for incident dementia, however the statistical power of this finding was limited. So, it seems that the association among Mediterranean diet, cognitive decline, and dementia risk still requires further study.

 

Source:

JAMA. 2009;302(6):638-648.

Created on: 08/19/2009
Reviewed on: 08/19/2009

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Biologist probe genes’ link to TB treatment

Filipino molecular biologists at the country’s largest pharmaceutical and healthcare company United Laboratories, Inc (Unilab) studied the genetic variations in a human body called single nucleotide polymorphisms (SNPs) that could determine the body’s response to TB treatment.

According to government data, TB is the sixth leading cause of death nationwide. This translates to 80 Filipinos dying from the disease daily, with two-thirds of the more than 85 million population harboring TB bacili and about 463,000 are active TB cases. These figures put RP at ninth rank in TB incidence worldwide.

The Unilab research team studied SNPs from blood obtained from healthy Filipino volunteers. Further study into these SNPs revealed that 47.3 percent of Filipinos are rapid acetylators, meaning their body can quickly break down an anti_TB drug like isoniazid, and thus have low risk to the toxic effects of the drugs.

The 11.6 percent are slow acetylators, which means anti-TB drugs like isoniazid stay longer in the patients’ blood, whichmay put them at a greater risk to the toxic effects of the drug.

“We plan to do more clinic studies on the remaining 41.1 percent of subjects who were found to be of the intermediate acetylator type.” Said Unilab medical director Alexander Tuazon. “Doing so will determine and verify the risk to isoniazid-induced liver toxicity.” (more…)

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