Posts Tagged ‘Heart Attack’

Elderly depression: The age factor in depression 2/2

Depression does not become more common as you get older, but it may become more complex.  Recent findings on age and depression confirm the so-called ‘U-curve’ of well being and happiness over the human life cycle.  Put simply, we’re at our most dissatisfied in our mid-forties – a finding that’s so in 47 of 55 countries surveyed. Depression seems to have much less of an impact in terms of daily disability in the older age groups.

But depression in the elderly is complicated by other diseases and it’s often hard to sort out cause and effect. Do you get depressed because you’ve had a heart attack? Does depression make it more likely that you’ll get diabetes? We really don’t know! Elderly depression is not so much about the numbers of people who are depressed, but more a matter of knowing how best to treat it.  Higher costs in terms of time, money and health care resources are involved in treating elderly depression and, too often, such resources simply aren’t adequate.  Moreover, the growing number of people over 60 (and, proportionately, even more so those over 80), means that elderly depression is set to rise dramatically. As yet, society seems unprepared for this.   Recent findings from the Zürich Study of younger persons (stretching over 20 years and with an age range of 20-41) have pointed to high levels of chronic depression existing alongside heart and lung problems, insomnia, pain (other than backache and headache) and sexual problems. Interestingly, the authors ascribe the heart and lung problems   in this age group as probably ‘associated with increased anxiety’.

In the elderly, by contrast, depression tends to exist alongside age-related conditions like stroke, high blood pressure, atrial fibrillation, diabetes, cancer and dementia.

The Zürich Study also found that other mental health problems co-exist with depression in the   20-41 age group. The six leading risk factors were found to be tobacco dependence, substance abuse, generalized anxiety disorder, obsessive-compulsive syndrome, panic attacks and alcohol use disorder. Again, with the exception of anxiety, these are probably more prominent risk factors for depression in younger persons than for the elderly. The psychosocial impact of bereavement, loneliness and growing physical and cognitive problems in coping with the normal activities of daily life are more characteristic associations with depression in old age.

The next article in this series looks at current   practice in the diagnosis and treatment of elderly depression.

 

Sources:

J. Angst, A. Gamma et al, “Long-term depression versus episodic major depression: results from the prospective Zürich study of a community sample”, J. Affective Disorders 115, 112-121, 2009
N. G. Choi & J. S. Kim, “Age group differences in depressive symptoms among older adults with functional impairments”, Health & Social Work 32[3], 177-188, August 2007

 

Related article:
Elderly and depression: How to understand Depression in the elderly 1/2

Created on: 11/04/2009
Reviewed on: 11/04/2009

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Ticagrelor May Be Better Option in Acute Coronary Syndrome

Acute coronary syndrome is the general term for any group of clinical symptoms compatible with an acute insufficiency of blood supply to the heart muscle due to coronary artery disease. Thus, acute coronary syndrome spans the spectrum from angina to heart attack. Platelet inhibitors such as clopidogrel, or Plavix, have been shown to improve outcomes in patients with acute coronary syndrome.

Now, as published online August 30, 2009 in the New England Journal of Medicine, scientists report that ticagrelor, or Brilinta, significantly reduces the rate of death from vascular causes, heart attack, or stroke compared with clopidogrel.

Investigators from the Study of Platelet Inhibition and Patients Outcomes (PLATO) performed a multicenter, double-blind, randomized trial comparing ticagrelor and clopidogrel for the prevention of cardiovascular events in 18,624 patients admitted to the hospital with an acute coronary syndrome. At 12 months, the investigators found the death from vascular causes, heart attack, or stroke had occurred in 9.8% of acute coronary syndrome patients receiving ticagrelor as compared with 11.7% of those receiving clopidogrel. This reduction was statistically significant. There was also a significant reduction in the rate of death from any cause among those acute coronary syndrome patients receiving ticagrelor.
 
A potentially fatal side effect of platelet inhibition is major bleeding. The PLATO investigators found no significant difference in the rates of major bleeding between the ticagrelor and clopidogrel groups, although ticagrelor was associated more instances of fatal bleeding within the brain. Based on these findings, the investigators conclude that, in patients who have an acute coronary syndrome, treatment with ticagrelor significantly reduced the rate of death from vascular causes, myocardial infarction, or stroke without an increase in the rate of overall major bleeding.
 

Source:

NEJM. Published at www.nejm.org August 30, 2009.

Created on: 09/11/2009
Reviewed on: 09/11/2009

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Combination Lipid Therapy No Better Than Statins

Cholesterol-lowering therapy with statins effectively prevents cardiovascular disease, but treatment with statins does not guarantee that cholesterol targets are reached. In cases where intensive lipid-lowering is needed, physicians sometimes combine statins with other lipid-modifying medications. However, according to a review published online before print September 1, 2009 in Annals of Internal Medicine, limited evidence suggests that combinations of lipid-lowering agents do not improve clinical outcomes more than high-dose statins alone.

Researchers from the University of Ottawa in Ontario, Canada and their colleagues reviewed 102 studies to compare the benefits and harms of high-dose statins versus combination lipid-lowering therapy in adults at high risk for coronary artery disease. They found very-low-strength evidence that combination lipid-lowering therapy did not reduce mortality more than high-dose statins, though two trials did show that combination therapy was more likely to attain cholesterol-lowering goals.
 
Overall, the researchers found no benefit for combination lipid-lowering therapy over high-dose statins for mortality, heart attack, stroke, or the need for a revascularization procedure. However, a limitation of the review was that most of the studies reviewed were short. Further research is needed to see if there is a difference in clinical outcomes between combination lipid-lower therapy and high-dose statins in the long term.
 

Source:

Ann Intern Med. Published online before print September 1, 2009.

Created on: 09/09/2009
Reviewed on: 09/09/2009

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Daily aspirin therapy for the heart: A user’s guide

by Tyrone M. Reyes, M.D.

Aspirin has long been known to relieve fevers, aches, and pains. But in recent years, it has also gained a reputation as a drug that can lower the risk of heart attack and clot-related stroke. As a result, millions of people around the world (50 million in the United States alone!) now take a daily dose of aspirin. So, if you’ve had heart problems or doctors have found evidence of atherosclerosis in your arteries, the advice today about aspirin is clear and gender neutral: A daily dose will reduce your chances of dying of heart attack or stroke. Although there are still some doubts about the optimal dose, most studies show that small doses are just as effective — and maybe even more so — than large doses, so the standard advice is to take 75 to 162mg daily. In the United States and the Philippines, low-dose aspirin comes in 81-mg pills, which is basically the amount found in a “baby aspirin” tablet. In Europe, a 75-mg pill is available. (more…)

Simple health screening tests you absolutely need

by Tyrone M. Reyes, M.D.

The single biggest killer of adults over 65 is chronic disease. Heart disease, cancer, and stroke account for nearly two-thirds of all deaths among people, aged 65 and older. The real tragedy is that many of these diseases are preventable with lifestyle changes and careful screening. Too many older Filipinos aren’t getting screened, though — even those who can afford it. It is probably safe to say that fewer than one in 10 seniors get all of their recommended screenings and immunizations.

“People are often afraid of having some of these tests or get complacent when their results have been okay in the past,” says Audrey Chun, MD, medical director of the Coffey Geriatrics practice at the Mount Sinai School of Medicine in New York. “But these tests can save your life. Catching high blood pressure, glucose, and cholesterol early can prevent diseases like heart attack and stroke. Detecting cancer earlier means a better likelihood of a cure.”

Here are simple tests you absolutely need on a regular basis: (more…)

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