Posts Tagged ‘Rsquo’

Elderly depression: The age factor in depression 2/2

Depression does not become more common as you get older, but it may become more complex.  Recent findings on age and depression confirm the so-called ‘U-curve’ of well being and happiness over the human life cycle.  Put simply, we’re at our most dissatisfied in our mid-forties – a finding that’s so in 47 of 55 countries surveyed. Depression seems to have much less of an impact in terms of daily disability in the older age groups.

But depression in the elderly is complicated by other diseases and it’s often hard to sort out cause and effect. Do you get depressed because you’ve had a heart attack? Does depression make it more likely that you’ll get diabetes? We really don’t know! Elderly depression is not so much about the numbers of people who are depressed, but more a matter of knowing how best to treat it.  Higher costs in terms of time, money and health care resources are involved in treating elderly depression and, too often, such resources simply aren’t adequate.  Moreover, the growing number of people over 60 (and, proportionately, even more so those over 80), means that elderly depression is set to rise dramatically. As yet, society seems unprepared for this.   Recent findings from the Zürich Study of younger persons (stretching over 20 years and with an age range of 20-41) have pointed to high levels of chronic depression existing alongside heart and lung problems, insomnia, pain (other than backache and headache) and sexual problems. Interestingly, the authors ascribe the heart and lung problems   in this age group as probably ‘associated with increased anxiety’.

In the elderly, by contrast, depression tends to exist alongside age-related conditions like stroke, high blood pressure, atrial fibrillation, diabetes, cancer and dementia.

The Zürich Study also found that other mental health problems co-exist with depression in the   20-41 age group. The six leading risk factors were found to be tobacco dependence, substance abuse, generalized anxiety disorder, obsessive-compulsive syndrome, panic attacks and alcohol use disorder. Again, with the exception of anxiety, these are probably more prominent risk factors for depression in younger persons than for the elderly. The psychosocial impact of bereavement, loneliness and growing physical and cognitive problems in coping with the normal activities of daily life are more characteristic associations with depression in old age.

The next article in this series looks at current   practice in the diagnosis and treatment of elderly depression.

 

Sources:

J. Angst, A. Gamma et al, “Long-term depression versus episodic major depression: results from the prospective Zürich study of a community sample”, J. Affective Disorders 115, 112-121, 2009
N. G. Choi & J. S. Kim, “Age group differences in depressive symptoms among older adults with functional impairments”, Health & Social Work 32[3], 177-188, August 2007

 

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Elderly and depression: How to understand Depression in the elderly 1/2

Created on: 11/04/2009
Reviewed on: 11/04/2009

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Depression in the elderly – how to understand it

Depression is perhaps the most frequent cause of emotional suffering in later life’ said Dan G Blazer, Professor of Psychiatry at DukeUniversity.  Being socially isolated, particularly after the death of a partner, and co-existing illness may contribute towards depression in older people.  Depression often goes undiagnosed or untreated so it becomes an increasing public health issue in our ageing society.  The challenge, then, is more one of managing depression effectively in later life rather than understanding the condition.

How widespread is depression among older people? Recent surveys suggest a prevalence between 1.8% in the over 55s to 15% in those over 85.  While depression is actually less prevalent among the old, compared to the young,  major depression may be more common.  There is also a clear link between chronic disease and depression, with those in nursing homes showing higher rates than those living in the community. But is the link a causal one? We know that illness can cause depression (and vice versa), but we cannot be sure residents of nursing homes are depressed because they are ill or because their care is not sufficiently ‘caring’.

And when it comes to the gender gap, it’s well known that women are more prone to depression in Europe and North America.  But a new study from China, covering 2,633 adults, showed that the gender difference is insignificant, save in the 35-49 age group where lifetime prevalence for major depression for men was 3.6% compared to 2.3% for women.

There is also a cultural dimension to elderly depression. A meta-analysis of nine European centres revealed a prevalence of 8.8% in Iceland in the 88-89 age group compared to 23.6% in Munich in the over 85s.  And, among the ‘oldest old’ 2% declared ‘life not worth living’ and 3% ‘wish to be dead’ in Iceland, compared to 16% and 25% in Berlin and 30% and 29% in Munich. The researchers wondered if some lingering distress from the Second World War could account for high rates of depression among very elderly Germans.

Finally, a number of risk factors for elderly depression have been identified, including medical burden, bereavement, chronic insomnia, cerebrovascular disease, Alzheimer’s disease and Parkinson’s disease.  In the next article in this series, we will explore differences between depression in elderly and young persons.


Source:

adapted from ‘Elderly depression. 1. Its prevalence, causes and implications for societyHeinz Redwood, August 2009.

Created on: 09/07/2009
Reviewed on: 09/07/2009

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Mediterranean Diet and Physical Activity Reduce Alzheimer’s Risk

 Previous studies have shown that a Mediterranean diet and higher physical activity are each associated with a lower risk of Alzheimer’s disease.

However, the combined association of Mediterranean diet and more physical activity on Alzheimer’s risk is not well-studied. In the August 12, 2009 issue of Journal of the American Medical Association, researchers report that both eating well and participating in physical activity may independently confer Alzheimer’s disease-related health benefits.

 

Researchers from Columbia University studied 1880 community-dwelling elderly individuals living in New York City who did not have Alzheimer’s dementia. Both diet and physical activity information were available for each of these individuals. The researchers administered neurological and neuropsychological testing approximately every 1.5 years from 1992 through 2006. During this time, a total of 282 cases of Alzheimer’s disease were diagnosed. Both Mediterranean diet and higher levels of physical activity were associated with a lower risk of Alzheimer’s disease.

 

While some may argue that the association between physical activity and Alzheimer’s disease simply reflect that more physically active people are also more likely to eat healthier, this study demonstrates that the associations of diet and physical activity with lower rates of Alzheimer’s disease were independent of each other. Based on this study, even a relatively small amount of physical activity (1.3 hours of vigorous physical activity or 2.4 hours of moderate physical activity or 4 hours of light physical activity per week) was associated with a reduction in Alzheimer’s risk.

 

Source:

JAMA. 2009;302(6):627-637.

Created on: 08/20/2009
Reviewed on: 08/20/2009

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Healthy heart means healthy brain

Alzheimer’s disease is said to affect one in six Americans over the age of 70.  There’s an increasing focus upon how health, and particularly heart health, in mid life affects your chances of developing Alzheimer’s disease in later life. 

A new report from the long-running Atherosclerosis Risk in Communities (ARIC) study now reveals that diabetes, high blood pressure and smoking in earlier years significantly increase the risk of Alzheimer’s disease.  The researchers, from a number of centers in the United States, studied over 11,000 ARIC participants who were in the study in 1990 to 1992 to see which ones were hospitalized for Alzheimer’s disease during follow up.  This data on Alzheimer’s disease cases was linked to heart health factors like diabetes, smoking, obesity and high blood pressure.

The findings of this ARIC study tell us a lot about Alzheimer’s disease prevention.  Those who smoked were 70% more likely to develop Alzheimer’s disease.  Those who had high blood pressure had a 60% increased risk.  Diabetes doubles the risk of Alzheimer’s disease.  However, in this study, obesity appeared not to be a risk factor for Alzheimer’s disease – this does contradict findings from previous work.  When the risk factors were present at a younger age, the risk of Alzheimer’s disease was higher.

People are increasingly aware on how to keep their heart healthy – through avoiding diabetes, high blood pressure and other risk factors. It is interesting that these factors also influence the risk of Alzheimer’s disease.  It may be that there is a common underlying mechanism affecting both heart and brain – perhaps hardening and thickening of the arteries, reducing blood supply to both organs.  Therefore, heart health and brain health appear to be inextricably linked and the same lifestyle efforts will help both aspects of long term health. 

 

Source:

Alonso A, Mosley T et al Risk of dementia hospitalisation associated with cardiovascular risk factors in midlife and older age: the Atherosclerosis Risk in Communities (ARIC) study Journal of Neurology Neurosurgery and Psychiatry August 2009; doi:10.1136/jnnp.2009.176818

Created on: 08/14/2009
Reviewed on: 08/14/2009

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FDA Approves New Cholesterol Drug

Last week, the U.S. Food and Drug Administration (FDA) approved pitavastatin, a new cholesterol-lowering drug. Pitavastatin is indicated for the primary treatment of high cholesterol and combined dyslipidemia.

Pitavastatin, which will be marketed as Livalo®, is the newest statin therapy to be introduced for cholesterol-lowering. The FDA’s approval of pitavastatin is based upon evidence from five Phase III trials demonstrating its efficacy in lowering low density lipoprotein (LDL) cholesterol in elderly patients, diabetics, and patients at higher cardiovascular risk.
 
Livalo is expected to launch in the U.S. in early 2010, and this cholesterol-lowering drug will be available in three dosages.
 

Source:

U.S. Food and Drug Administration website, accessed August 5, 2009.

Created on: 08/14/2009
Reviewed on: 08/14/2009

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